The European premiere of 150 Milligrams (La fille de Brest) will open the 64th edition of the San Sebastian Festival. The fifth feature by French director Emmanuelle Bercot, a contender for the Golden Shell, stars the Danish actress Sidse Babett Knudsen (Borgen) and the French actor Benoît Magimel (La Haine).

150 Milligrams (La fille de Brest) is based on novel “Mediator 150 mg” by Irène Frachon, a doctor who discovered in a Brest hospital the direct relationship between a drug and a number of suspicious deaths. Frachon sets out single-handed on a crusade to reveal the truth.


Based on the book by Irène Frachon Mediator 150mg. In the hospital where she works in Brest, France, a lung specialist discovers a direct link between suspicious deaths and state-approved medicine. She fights single-handedly for the truth to come out. The story of Irène Frachon, who broke the MEDIATOR scandal.

Emmanuelle Bercot (Paris, 1967), filmmaker, actress and screenwriter, has worked with directors such as Olivier Assayas and Bertrand Tavernier and landed Best Actress in Cannes last year for Mon roi (My King), by Maïwenn. Last year the Cannes Festival opened with her fourth feature film, La Tête haute (Standing Tall), where she also sounds out the French social system. The moviemaker’s third film, Elle s’en va (On My Way), premiered at the Berlinale.

The actress Sidse Babett Knudsen (Copenhagen, 1968), who plays the part of Irène Frachon, has worked with Susanne Bier, three-time competitor in San Sebastian’s Official Selection. Last year she won the Best Supporting Actress César for her part in L’Hermine (Courted), directed by Christian Vincent, which premiered in Venice. Her part in the series Borgen, about the dilemmas faced by Prime Minister Birgitte Nyborg, has earned her enormous popularity as an actress.

The career of French actor Benoît Magimel includes films helmed by moviemakers including Claude Chabrol, Jean Becker, Michael Haneke, Xavier Beauvois, Andre Téchiné and Mathieu Kassovitz. He won Best Actor in Cannes for La pianiste (The Piano Teacher) and the Best Supporting Actor César for his part in Bercot’s previous film, La Tête haute.

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