Actress Anne Heche, known starring in films Donnie Brasco, Wag the Dog, Six Days, Seven Nights and in Gus Van Sant’s remake of the horror film Psycho, died on Sunday in Los Angeles. She was 53.

Heche was critically injured on August 5 when a Mini Cooper she was driving crashed into a two-story home in the Mar Vista neighborhood of Los Angeles. Heche sustained burns and a severe anoxic brain injury, caused by a lack of oxygen to the brain.

Heche was declared brain-dead on August 12, but was kept on life support to determine if any of her organs were viable for donation.

In addition to her major film roles, Heche also starred in independent films, such as the drama film Birth, the sex comedy film Spread, the drama film Rampart, and the black comedy film Catfight.