In the new comedy by Pedro Almodóvar, and starring Antonio de la Torre, Hugo Silva, Miguel Ángel Silvestre, Laya Martí, Javier Cámara, Carlos Areces, Raul Arevalo, José María Yazpik, Guillermo Toledo, José Luis Torrijo, Lola Dueñas, Cecilia Roth, Blanca Suárez, a very mixed group of travelers are in a life-threatening situation on board a plane flying to Mexico City.
A technical failure has endangered the lives of the people on board Peninsula Flight 2549. The pilots are striving, along with their colleagues in the Control Center, to find a solution. The flight attendants and the chief steward are atypical, baroque characters who, in the face of danger, try to forget their own personal problems and devote themselves body and soul to the task of making the flight as enjoyable as possible for the passengers, while they wait for a solution. Life in the clouds is as complicated as it is at ground level, and for the same reasons, which could be summarized in two: sex and death.